Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP4B1 | P13584 | 2/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.40 |
| ▸ | CYP2A7 | P20853 | 2/20 | 0.40 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.40 |
| ▸ | CYP2F1 | P24903 | 2/20 | 0.40 |
| ▸ | CYP2C18 | P33260 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467257 | 0.93 | TOP1 (0.41) | CYP1A2CYP3A4CYP2C9CYP2B6DYRK1A | |
| SCHEMBL7468941 | 0.78 | PDE4B (0.40) | BACE1LMNAMAPTTSHRNPSR1 | |
| SCHEMBL7467196 | 0.77 | PDGFRB (0.35) | FYNADORA2A | |
| SCHEMBL9052406 | 0.77 | FYN (0.46) | ABL1ABCB1BCRBACE1FYN | |
| SCHEMBL7355495 | 0.75 | HPRT1 (0.38) | BACE1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5779607 | 0.74 | CYP1A1 (0.45) | CYP1A1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL7470694 | 0.74 | SQOR (0.40) | ADORA1 | |
| SCHEMBL7462457 | 0.73 | AKR1C3 (0.46) | LMNAMAPTTSHRRAB9ASMN1; SMN2 | |
| SCHEMBL9955938 | 0.72 | PTGS2 (0.36) | DYRK1ARAB9A | |
| SCHEMBL1180412 | 0.72 | ABL1 (0.77) | ABL1ABCB1BCRCYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009823-A9 | HYPOGLYCEMIC AGENT FROM CRYPTOLEPIS | — | 1996-05-23 | — | — | WO | claimed |
| WO-1996009823-A1 | HYPOGLYCEMIC AGENT FROM CRYPTOLEPIS | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | claimed |
| EP-0618900-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS. | BOOTS CO PLC (GB) | 1994-10-12 | — | — | EP | disclosed |