Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | PGD | P52209 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL9055269 | 0.81 | MEN1 (0.36) | — | |
| Acrylic Acid SCHEMBL6128971 | 0.76 | LMNA (0.43) | LPAR2LPAR3FNTAFNTBPGD | |
| Methacrylic Acid SCHEMBL3464507 | 0.75 | FNTA (0.40) | LPAR2LPAR3FNTAFNTBPGD | |
| Dimethylamine SCHEMBL17629688 | 0.74 | LPAR3 (0.44) | LPAR2LPAR3FNTAFNTB | |
| SCHEMBL15847030 | 0.74 | LPAR3 (0.50) | LPAR2LPAR3FNTAFNTB | |
| SCHEMBL30321 | 0.74 | — | — | |
| SCHEMBL27856708 | 0.73 | LPAR2 (0.42) | LPAR2LPAR3FNTAFNTBPGD | |
| Methane SCHEMBL4957355 | 0.72 | LPAR3 (0.48) | LPAR2LPAR3FNTAFNTB | |
| SCHEMBL11598005 | 0.72 | — | — | |
| Ethylene SCHEMBL6264686 | 0.72 | LPAR3 (0.48) | LPAR2LPAR3FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446636-B1 | External application base or auxiliary agent and external application composition for human being or animal containing the same | SHOWA DENKO KK (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-5455042-A | Ointment comprising a homogenous mixture of a polymer or copolymer of N-vinylacetamide, water and/or alcohols, and a pharmacologically active component | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1995-10-03 | — | — | US | disclosed |
| US-5344655-A | Drug delivery | SHOWA DENKO K.K. (JP) | 1994-09-06 | — | — | US | disclosed |
| US-5254338-A | N-vinylacetamide polymer | SHOWA DENKO K.K. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0446636-A2 | External application base or auxiliary agent and external application composition for human being or animal containing the same | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1991-09-18 | — | — | EP | disclosed |