Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9055001 | 0.88 | SMN1; SMN2 (0.38) | TSHRLMNAALDH1A1KDM4ECES1 | |
| SCHEMBL9056288 | 0.86 | ALDH1A1 (0.41) | TSHRLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9056121 | 0.85 | CES1 (0.39) | TSHRLMNAALDH1A1CES1MEN1 | |
| SCHEMBL9055477 | 0.77 | CES1 (0.41) | ALDH1A1CASP1CASP7CES1ALDH2 | |
| SCHEMBL9207029 | 0.77 | CES1 (0.40) | LMNAALDH1A1CASP1CASP7HSD17B10 | |
| SCHEMBL9055513 | 0.75 | CASP3 (0.47) | TSHRALDH1A1KDM4ECASP1CASP7 | |
| SCHEMBL9057244 | 0.74 | CASP3 (0.48) | TSHRALDH1A1KDM4ECASP1CASP7 | |
| SCHEMBL23412593 | 0.69 | ALDH1A1 (0.49) | ALDH1A1CES1ALDH2ALDH3A1 | |
| SCHEMBL9177591 | 0.68 | CASP3 (0.39) | TSHRLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL8134987 | 0.67 | SMN1; SMN2 (0.42) | TSHRLMNAALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522494-B1 | Novel isatineoxime derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1996-10-02 | — | — | EP | disclosed |
| US-5223527-A | Isatineoxime derivatives and their use | NEUROSEARCH A/S (DK) | 1993-06-29 | — | — | US | disclosed |
| EP-0522494-A1 | Novel isatineoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-01-13 | — | — | EP | disclosed |