Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057885 | 0.86 | BACE1 (0.43) | HSD17B10MTNR1AMTNR1BAPLNRALDH1A1 | |
| SCHEMBL7847833 | 0.81 | LMNA (0.38) | HSD17B10ALDH1A1KMT2A | |
| SCHEMBL9055664 | 0.81 | APLNR (0.49) | APLNRALDH1A1MEN1KMT2A | |
| SCHEMBL28383367 | 0.79 | CA12 (0.59) | HSD17B10ALDH1A1CA2MEN1KMT2A | |
| SCHEMBL590943 | 0.78 | APLNR (0.63) | APLNRALDH1A1DYRK1ACA2GFER | |
| SCHEMBL8804635 | 0.76 | LMNA (0.54) | HSD17B10POLBMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL4039880 | 0.75 | APLNR (0.59) | APLNRALDH1A1DYRK1ACA2GFER | |
| SCHEMBL9055043 | 0.74 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2ABACE1NPC1 | |
| SCHEMBL2838782 | 0.72 | BACE1 (0.51) | HSD17B10APLNRALDH1A1MEN1KMT2A | |
| SCHEMBL29576414 | 0.72 | KMT2A (0.53) | HSD17B10MTNR1AMTNR1BAPLNRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996012706-A1 | NOVEL ACID PYRAZOLE AND PYRAZOLONE DERIVATIVES FOR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | ROUSSEL UCLAF (FR) | 1996-05-02 | — | — | WO | disclosed |