Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478215 | 0.89 | NPC1 (0.42) | TP53ALDH1A1NPC1JAK2RAB9A | |
| SCHEMBL4611261 | 0.76 | NPC1 (0.46) | TP53ALDH1A1NPC1JAK2RAB9A | |
| SCHEMBL11124464 | 0.71 | MAPT (0.47) | TP53ALDH1A1NPC1JAK2RAB9A | |
| SCHEMBL2522993 | 0.70 | HTR1A (0.40) | TP53ESR1 | |
| SCHEMBL1770692 | 0.69 | ESR1 (0.43) | TP53ALDH1A1TSHRCYP3A4LMNA | |
| SCHEMBL6567717 | 0.68 | ALDH1A1 (0.52) | TP53ALDH1A1NPC1JAK2RAB9A | |
| SCHEMBL3784268 | 0.67 | ALDH1A1 (0.50) | TP53ALDH1A1NPC1JAK2RAB9A | |
| SCHEMBL8812805 | 0.67 | HSD17B10 (0.43) | ALDH1A1NPC1RAB9ATSHRCYP3A4 | |
| SCHEMBL6567779 | 0.67 | ALDH1A1 (0.50) | TP53ALDH1A1NPC1JAK2RAB9A | |
| SCHEMBL6566239 | 0.67 | ALDH1A1 (0.50) | TP53ALDH1A1NPC1JAK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552765-B1 | Benzimidazoles, pharmaceutical compositions containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1996-08-14 | — | — | EP | disclosed |
| EP-0581166-A1 | Benzimidazoles, process for their preparation and their use as angiotensin-II antagonists | Dr. Karl Thomae GmbH (DE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0552765-A1 | Benzimidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |