SCHEMBL9058158

SCHEMBL9058158

O=C(O)C1C2C=CC(O2)C1C(=O)Cl

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPM1B O75688 3/20 0.52
HSD17B10 Q99714 1/20 0.45
ALDH1A1 P00352 8/20 0.41
KDM4E B2RXH2 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KMT2A Q03164 2/20 0.41
TP53 P04637 1/20 0.41
GAA P10253 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
LMNA P02545 2/20 0.40
TAAR1 Q96RJ0 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12762660 0.91 PPM1B (0.39) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL13897079 0.88 PPM1B (0.61) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL9697481 0.88 PPM1B (0.61) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL6778458 0.88 PPM1B (0.61) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL13480836 0.88 PPM1B (0.61) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL1005051 0.88 PPM1B (0.61) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL11393084 0.88 PPM1B (0.61) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL9880145 0.77 PPM1B (0.56) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL13002242 0.77 PPM1B (0.52) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1
SCHEMBL819846 0.77 PPM1B (0.56) PPM1BHSD17B10ALDH1A1KDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8187623-B2 Medical copolymers BOSTON SCIENTIFIC SCIMED, INC. (US) 2012-05-29 US disclosed
US-20090324679-A1 MEDICAL COPOLYMERS BOSTON SCIENTIFIC SCIMED, INC. (US) 2009-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090324679-A1 MEDICAL COPOLYMERS CCR9, CTR9, F9 PPM1B 1619/4885HSD17B10 1382/4885ALDH1A1 3624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.