Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675540 | 1.00 | PPM1B (0.56) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL819846 | 1.00 | PPM1B (0.56) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL14516610 | 0.91 | PPM1B (0.44) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL13480836 | 0.88 | PPM1B (0.61) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL13897079 | 0.88 | PPM1B (0.61) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL6778458 | 0.88 | PPM1B (0.61) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL1005051 | 0.88 | PPM1B (0.61) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL11393084 | 0.88 | PPM1B (0.61) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL9697481 | 0.88 | PPM1B (0.61) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL13002242 | 0.77 | PPM1B (0.52) | PPM1BALDH1A1KMT2AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170259081-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | LIXTE BIOTECHNOLOGY, INC. (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170259081-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | LIXTE BIOTECHNOLOGY, INC. (US) | 2017-09-14 | — | — | US | disclosed |
| US-9526915-B2 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase | LIXTE BIOTECHNOLOGY, INC. | 2016-12-27 | — | — | US | disclosed |
| US-20130280210-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | LIXTE BIOTECHNOLOGY, INC. | 2013-10-24 | — | — | US | disclosed |
| US-8329719-B2 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120135522-A1 | METHODS OF MODULATING CELL REGULATION BY INHIBITING P53 | LIXTE BIOTECHNOLOGY, INC. | 2012-05-31 | — | — | US | disclosed |
| US-20110287537-A1 | NEUROPROTECTIVE AGENTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES | LIXTE BIOTECHNOLOGY, INC. | 2011-11-24 | — | — | US | disclosed |
| US-8058268-B2 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20100029683-A1 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses | LIXTE BIOTECHNOLOGY, INC. | 2010-02-04 | — | — | US | disclosed |
| US-20100029484-A1 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. | 2010-02-04 | — | — | US | disclosed |
| US-20100029640-A1 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. | 2010-02-04 | — | — | US | disclosed |
| US-20090035292-A1 | Use of phosphatases to treat neuroblastomas and medulloblastomas | LIXTE BIOTECHNOLOGY, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029640-A1 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | SNCA, NLN, HTT | PPM1B 2358/4885ALDH1A1 1929/4885KMT2A 3224/4885 |
| US-20100029683-A1 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses | PSPH, PPP5C, BUB1B | PPM1B 184/4885ALDH1A1 4732/4885KMT2A 3789/4885 |
| US-20100029484-A1 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | HCCS, OXA1L, OTC | PPM1B 3573/4885ALDH1A1 358/4885KMT2A 1912/4885 |
| US-20130280210-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | PPP5C, BUB1B, CDC25C | PPM1B 149/4885ALDH1A1 4528/4885KMT2A 3099/4885 |
| US-20170259081-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | PPP5C, BUB1B, CDC25C | PPM1B 149/4885ALDH1A1 4528/4885KMT2A 3099/4885 |
| US-20090035292-A1 | Use of phosphatases to treat neuroblastomas and medulloblastomas | PPME1, PNKP, PPP6C | PPM1B 15/4885ALDH1A1 811/4885KMT2A 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.