Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.66 |
| ▸ | RXRA | P19793 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | LIPE | Q05469 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30416387 | 0.92 | HTR1A (0.74) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL791853 | 0.92 | HTR1A (0.74) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| Ammonia Solution, Strong SCHEMBL2063054 | 0.90 | HTR1A (0.72) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| Ethylamine SCHEMBL28464910 | 0.84 | HTR1A (0.64) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL339812 | 0.82 | MAPT (0.71) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL9474602 | 0.81 | APP (0.69) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL16437065 | 0.81 | MAPT (0.55) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL9615215 | 0.81 | MRGPRX4 (0.69) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL19361334 | 0.80 | NPC1 (0.52) | HTR1AADRA1DADRA1AADRA1BRXRA | |
| SCHEMBL16823466 | 0.80 | RXRA (1.00) | RXRAATMAPPMRGPRX4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732046-B2 | Substituted 1,2,4-triazines as tubulin inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160031835-A1 | TUBULIN INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY LTD. | 2016-02-04 | — | — | US | disclosed |
| US-9139560-B2 | Substituted pyrazines as tubulin inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD. (US) | 2015-09-22 | — | — | US | disclosed |
| EP-2277865-B1 | Phenyl-substituted 6-ring nitrogen-heterocycles as microtubule polymerisation inhibitors | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2014-11-12 | — | — | EP | disclosed |
| US-20140221396-A1 | TUBULIN INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY LTD. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130274263-A1 | TUBULIN INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY LTD | 2013-10-17 | — | — | US | disclosed |
| US-8394806-B2 | 2-phenyl pyrazines as tubulin inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2013-03-12 | — | — | US | disclosed |
| US-20110269760-A1 | TUBULIN INHIBITORS | CYTOPIA RESEARCH PTY LTD (AU) | 2011-11-03 | — | — | US | disclosed |
| US-7981900-B2 | Modulation microtubules diseases; antiproliferative agents; antiinflamamtory agents | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-07-19 | — | — | US | disclosed |
| EP-1689715-B1 | TUBULIN INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2011-02-09 | — | — | EP | disclosed |
| EP-2277865-A1 | Phenyl-substituted 6-ring nitrogen-heterocycles as microtubule polymerisation inhibitors | YM BioSciences Australia Pty Ltd (AU) | 2011-01-26 | — | — | EP | disclosed |
| US-20080194583-A1 | Tubulin Inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD | 2008-08-14 | — | — | US | disclosed |
| EP-1689715-A4 | TUBULIN INHIBITORS | CYTOPIA RES PTY LTD (AU) | 2008-01-23 | — | — | EP | disclosed |
| EP-1689715-A1 | TUBULIN INHIBITORS | Cytopia Research Pty Ltd (AU) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005054199-A1 | TUBULIN INHIBITORS | CYTOPIA RESEARCH PTY LTD (AU) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031835-A1 | TUBULIN INHIBITORS | TUBB1, TUBB3, TUBA1C | HTR1A 4544/4885ADRA1D 2566/4885ADRA1A 2728/4885 |
| US-20080194583-A1 | Tubulin Inhibitors | TUBB1, TUBB3, TUBA1C | HTR1A 4554/4885ADRA1D 2586/4885ADRA1A 2828/4885 |
| US-20110269760-A1 | TUBULIN INHIBITORS | TUBB1, TUBB3, TUBA1C | HTR1A 4544/4885ADRA1D 2566/4885ADRA1A 2728/4885 |
| US-20130274263-A1 | TUBULIN INHIBITORS | TUBB1, TUBB3, TUBA1C | HTR1A 4544/4885ADRA1D 2566/4885ADRA1A 2728/4885 |
| US-20140221396-A1 | TUBULIN INHIBITORS | TUBB1, TUBB3, TUBA1C | HTR1A 4544/4885ADRA1D 2566/4885ADRA1A 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.