SCHEMBL9062240

SCHEMBL9062240

CCCOc1ccc(CCc2ccc(OC(F)(F)F)cc2)c(F)c1F

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 5/20 0.41
HCRTR2 O43614 5/20 0.41
FFAR4 Q5NUL3 1/20 0.37
TSHR P16473 1/20 0.37
DAO P14920 1/20 0.37
SLC6A4 P31645 4/20 0.36
SLC6A3 Q01959 3/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
LMNA P02545 1/20 0.36
GPR84 Q9NQS5 1/20 0.36
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
ALOX5 P09917 1/20 0.35
PPARG P37231 1/20 0.35
ALDH1A1 P00352 1/20 0.35
SCN8A Q9UQD0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9060258 0.95 ALOX5 (0.39) HCRTR1HCRTR2FFAR4TSHRDAO
SCHEMBL9061450 0.93 ALOX5 (0.38) HCRTR1HCRTR2FFAR4TSHRDAO
SCHEMBL9060352 0.91 HCRTR1 (0.44) HCRTR1HCRTR2FFAR4TSHRDAO
SCHEMBL10532774 0.89 PPARG (0.39) HCRTR1HCRTR2FFAR4DAOGPR84
SCHEMBL9061734 0.85 TSHR (0.43) FFAR4TSHRDAOSLC6A4SLC6A3
SCHEMBL20346150 0.82 FFAR4 (0.40) FFAR4L3MBTL1LMNAPPARDPPARA
SCHEMBL9060747 0.82 TSHR (0.41) TSHRDAOSLC6A4SLC6A3GPR84
SCHEMBL9061433 0.82 DAO (0.46) FFAR4TSHRDAOSLC6A4SLC6A3
SCHEMBL9061607 0.81 FAAH (0.41) TSHRDAOSLC6A4SLC6A3LMNA
SCHEMBL20346152 0.81 GLA (0.40) L3MBTL1PPARDPPARAPPARGALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5536442-A ELECTROOPTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1996-07-16 US disclosed
US-5324449-A Substituted phenyl trifluoromethyl ethers MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-06-28 US disclosed
EP-0334911-B1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1993-02-10 EP disclosed
EP-0334911-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1989-10-04 EP disclosed
WO-1989002884-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1989-04-06 WO disclosed