Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | BAX | Q07812 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467886 | 0.93 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| SCHEMBL11032753 | 0.86 | CXCR4 (0.44) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| SCHEMBL2477573 | 0.85 | ACE2 (0.42) | SMN1; SMN2ANPEPERAP2CXCR4RAD52 | |
| SCHEMBL8871405 | 0.80 | ACE2 (0.56) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| SCHEMBL8871392 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| SCHEMBL2945288 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| SCHEMBL22248563 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| Adipic Acid SCHEMBL9505699 | 0.75 | ITGB3 (0.43) | SMN1; SMN2CHRM5CHRM3SLC6A2ALOX15 | |
| SCHEMBL13833229 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBANPEPERAP2CXCR4 | |
| SCHEMBL713548 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBANPEPERAP2CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996017880-A1 | NOVEL POLYURETHANE TOUGHENER, THERMOSETTING RESIN COMPOSITIONS AND ADHESIVES | THE DEXTER CORPORATION (US) | 1996-06-13 | — | — | WO | disclosed |