Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9065017 | 0.96 | MAPT (0.51) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL3911817 | 0.87 | LMNA (0.39) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL7621011 | 0.85 | MAPT (0.49) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL1415624 | 0.83 | CASP3 (0.45) | MAPTSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL3909913 | 0.80 | MAPT (0.49) | MAPTSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL3909905 | 0.80 | MAPT (0.53) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL28825749 | 0.77 | HPGD (0.55) | MAPTSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9328298 | 0.77 | ALDH1A1 (0.51) | MAPTSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL3911808 | 0.75 | MAPT (0.52) | MAPTSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL3905204 | 0.73 | NPC1 (0.47) | MAPTSMN1; SMN2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536083-B1 | Process for the synthesis of dialkyl succinylsuccinate esters and their conversion to dialkyl 2,5-diarylamino-3,6-dihydroterephthalate esters | CIBA GEIGY AG (CH) | 1996-03-06 | — | — | EP | disclosed |
| EP-0536083-A1 | Process for the synthesis of dialkyl succinylsuccinate esters and their conversion to dialkyl 2,5-diarylamino-3,6-dihydroterephthalate esters | CIBA-GEIGY AG (CH) | 1993-04-07 | — | — | EP | disclosed |