SCHEMBL9065360

SCHEMBL9065360

CCc1c(C)cccc1Nc1ccc(Nc2cccc(C)c2CC)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.40
GAA P10253 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
RAB9A P51151 2/20 0.39
ALDH1A1 P00352 2/20 0.39
NPC1 O15118 1/20 0.39
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
KDM4E B2RXH2 2/20 0.38
HTT P42858 1/20 0.38
GLA P06280 1/20 0.38
RECQL P46063 1/20 0.38
PTGS2 P35354 1/20 0.37
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
MAPK13 O15264 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10310076 0.79 MAPT (0.40) MAPTGAATDP1RAB9AALDH1A1
SCHEMBL19122441 0.78 MAPT (0.43) MAPTGAAALDH1A1MEN1KMT2A
Ammonia Solution, Strong SCHEMBL9730743 0.76 MAPT (0.42) MAPTGAAALDH1A1MEN1KMT2A
SCHEMBL23341283 0.76 MAPT (0.47) MAPTGAATDP1RAB9AALDH1A1
SCHEMBL597056 0.75 CYP2A6 (0.45) MAPTTDP1ALDH1A1HTTCYP1A2
SCHEMBL1922752 0.74 RAPGEF4 (0.59) MAPTGAATDP1RAB9AALDH1A1
SCHEMBL108882 0.73 MAPT (0.54) MAPTGAATDP1RAB9AALDH1A1
SCHEMBL29653984 0.73 MAPT (0.54) MAPTGAATDP1RAB9AALDH1A1
SCHEMBL28538607 0.73 MAPT (0.48) MAPTGAATDP1RAB9AALDH1A1
SCHEMBL8414964 0.72 MAPT (0.47) MAPTGAAALDH1A1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737231-A1 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INDUSTRIES, INC. (KR) 1996-10-16 EP disclosed
WO-1995018181-A1 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INDUSTRIES, INC. (KR) 1995-07-06 WO disclosed