Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7757710 | 0.84 | CA1 (0.41) | LMNAALDH1A1TP53KDM4EMAPT | |
| SCHEMBL10701485 | 0.79 | CA1 (0.58) | LMNAALDH1A1TP53KDM4ECYP3A4 | |
| Tromethamine SCHEMBL22634026 | 0.78 | ALDH1A1 (0.48) | LMNAALDH1A1TP53KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL28054073 | 0.77 | CA1 (0.55) | LMNAALDH1A1TP53KDM4ECYP3A4 | |
| SCHEMBL28349686 | 0.77 | CA1 (0.55) | LMNAALDH1A1TP53KDM4ECYP3A4 | |
| Tromethamine SCHEMBL1243932 | 0.76 | CA1 (0.41) | LMNAALDH1A1TP53KDM4EMAPT | |
| Tromethamine SCHEMBL4283712 | 0.74 | CYP3A4 (0.41) | LMNAALDH1A1CYP3A4MAPK1HSD17B10 | |
| SCHEMBL20591154 | 0.72 | CA1 (0.44) | LMNAALDH1A1TP53KDM4ECYP3A4 | |
| Tromethamine SCHEMBL21753758 | 0.70 | CTSD (0.51) | LMNAALDH1A1TP53MAPTHPGD | |
| SCHEMBL6757087 | 0.69 | CA1 (0.50) | LMNAALDH1A1TP53KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488079-A | HEAT AND LIGHT STABILIZERS FOR OLEFINS USING PHOSPHINES | SANDOZ LTD. (CH) | 1996-01-30 | — | — | US | disclosed |