Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068410 | 1.00 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3467641 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3105641 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3105639 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL9067769 | 0.84 | MAPT (0.70) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL9067633 | 0.84 | MAPT (0.70) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL518631 | 0.83 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL2487154 | 0.82 | KYAT1 (0.52) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL1998080 | 0.82 | KYAT1 (0.52) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL8060308 | 0.82 | KYAT1 (0.52) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506228-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO., INC. (US) | 1996-04-09 | — | — | US | disclosed |