Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3105641 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL3467641 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL9068415 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL9068410 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL2487154 | 0.82 | KYAT1 (0.52) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL1998080 | 0.82 | KYAT1 (0.52) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL8060308 | 0.82 | KYAT1 (0.52) | SMN1; SMN2MAPTMAPK1L3MBTL1NPC1 | |
| SCHEMBL3941339 | 0.81 | CA1 (0.53) | SMN1; SMN2MAPTHSD17B10GAAALDH1A1 | |
| SCHEMBL20893356 | 0.81 | CA1 (0.53) | SMN1; SMN2MAPTHSD17B10GAAALDH1A1 | |
| SCHEMBL3941336 | 0.81 | CA1 (0.53) | SMN1; SMN2MAPTHSD17B10GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123451-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | WO | disclosed |
| US-20100273805-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 733 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | US | disclosed |
| US-20080255202-A1 | Phenylthioacetic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273805-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 733 | GRM5, GRM3, GRIK5 | SMN1; SMN2 1071/4885MAPT 1373/4885MAPK1 2165/4885 |
| US-20080255202-A1 | Phenylthioacetic Acid Derivatives and Use Thereof | PAH, TST, MPST | SMN1; SMN2 4675/4885MAPT 1228/4885MAPK1 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.