Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GNG2 | P59768 | 1/20 | 0.36 |
| ▸ | GNB1 | P62873 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11781112 | 0.96 | HTR2C (0.36) | NOS3NOS1NOS2CES1LMNA | |
| SCHEMBL4564527 | 0.81 | CHRNE (0.43) | NOS3NOS1NOS2CES1LMNA | |
| SCHEMBL19830022 | 0.75 | NOS3 (0.45) | NOS3NOS1NOS2CES1LMNA | |
| SCHEMBL28148527 | 0.74 | HTR2C (0.37) | CES1LMNAALDH1A1MEN1THRA | |
| SCHEMBL23950199 | 0.74 | LMNA (0.41) | CES1LMNAALDH1A1MEN1THRA | |
| SCHEMBL22102573 | 0.74 | METAP2 (0.48) | LMNAALDH1A1MEN1THRATHRB | |
| SCHEMBL13861836 | 0.73 | HTR2C (0.37) | CES1LMNAALDH1A1MEN1THRA | |
| SCHEMBL2049784 | 0.73 | GABRA1 (0.43) | LMNAALDH1A1MEN1THRATHRB | |
| SCHEMBL22705095 | 0.73 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL23385382 | 0.73 | NOS3 (0.33) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527830-A | Drugs for the treatment of cardiac arrest and other shock states | THE OHIO STATE UNIVERSITY (US) | 1996-06-18 | — | — | US | disclosed |