SCHEMBL9075228

SCHEMBL9075228

CN(C)c1ccc2c(c1)C=CC2CCC1C=Cc2cc(N(C)C)ccc21

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.34
TSHR P16473 4/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TERT O14746 1/20 0.33
APP P05067 1/20 0.33
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27978597 0.76 ALDH1A1 (0.36) ALDH1A1TSHRALOX15HSD17B10TERT
SCHEMBL28331506 0.75 ALDH1A1 (0.34) ALDH1A1TSHRALOX15HSD17B10TERT
Hydrochloric Acid SCHEMBL27519712 0.75 ALDH1A1 (0.34) ALDH1A1TSHRALOX15HSD17B10TERT
SCHEMBL27978340 0.74 TERT (0.36) ALDH1A1TSHRALOX15HSD17B10TERT
SCHEMBL27978586 0.74 ALDH1A1 (0.33) ALDH1A1TSHRALOX15HSD17B10TERT
Hydrochloric Acid SCHEMBL27331246 0.74 ALDH1A1 (0.33) ALDH1A1TSHRALOX15HSD17B10TERT
Hydrochloric Acid SCHEMBL6918894 0.70 HTR1A (0.32) ALDH1A1TSHRALOX15HSD17B10TERT
SCHEMBL6918895 0.68
SCHEMBL9075311 0.67 IGLV6-57 (0.33)
Methylamine SCHEMBL28004018 0.66 HTR6 (0.56) ALDH1A1ALOX15HSD17B10CYP3A4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5545785-A Process for preparing biscyclopentadienyl compounds WITCO GMBH (DE) 1996-08-13 US disclosed
US-5474716-A Process for the preparation of bridged cyclopentadienylmagnesium compounds and use thereof for preparing metallocenes WITCO GMBH (DE) 1995-12-12 US disclosed
US-5453221-A Bridged cyclopentadienylmagnesium compounds and use thereof for preparing metallocenes WITCO GMBH (DE) 1995-09-26 US disclosed