Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9075109 | 0.84 | OPRM1 (0.46) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL9073468 | 0.84 | SIGMAR1 (0.55) | HTR1ADRD2DRD3SIGMAR1 | |
| SCHEMBL9075810 | 0.81 | KCNH2 (0.61) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL9075124 | 0.81 | HTR1A (0.55) | HTR1AOPRD1OPRK1OPRM1SETD7 | |
| SCHEMBL6452266 | 0.79 | KCNH2 (0.51) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL11868740 | 0.79 | OPRM1 (0.42) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL11858351 | 0.78 | OPRM1 (0.48) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL1968862 | 0.78 | LMNA (0.64) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL11859416 | 0.78 | OPRM1 (0.41) | HTR1AOPRD1OPRK1OPRM1P2RX7 | |
| SCHEMBL11860229 | 0.77 | KCNH2 (0.56) | HTR1AOPRD1OPRK1OPRM1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563134-B1 | AGENTS FOR POTENTIATING THE EFFECTS OF ANTITUMOR AGENTS AND COMBATING MULTIPLE DRUG RESISTANCE | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | disclosed |
| US-5416091-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS WELLCOME CO. (US) | 1995-05-16 | — | — | US | disclosed |