Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | CXCR6 | O00574 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9021809 | 0.96 | DRD2 (0.50) | DRD2DRD4HTR4CXCR6TSHR | |
| Fumaric Acid SCHEMBL9021549 | 0.93 | DRD2 (0.50) | DRD2DRD4HTR4CXCR6TSHR | |
| Fumaric Acid SCHEMBL9021486 | 0.93 | DRD2 (0.50) | DRD2DRD4HTR4CXCR6TSHR | |
| SCHEMBL9021504 | 0.93 | DRD2 (0.51) | DRD2DRD4HTR4CXCR6TSHR | |
| Fumaric Acid SCHEMBL9023503 | 0.90 | TMEM97 (0.39) | DRD2DRD4CXCR6TSHRCXCR4 | |
| SCHEMBL9022191 | 0.90 | DRD2 (0.54) | DRD2DRD4HTR4CXCR6TSHR | |
| SCHEMBL9021762 | 0.90 | HTR4 (0.51) | DRD2DRD4HTR4 | |
| SCHEMBL9021985 | 0.89 | DRD2 (0.52) | DRD2DRD4HTR4CXCR6TSHR | |
| SCHEMBL9021950 | 0.89 | DRD2 (0.52) | DRD2DRD4HTR4CXCR6TSHR | |
| SCHEMBL9021726 | 0.89 | DRD2 (0.52) | DRD2DRD4HTR4CXCR6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500422-A | FOR TREATING GASTROINTESTINAL DISEASES | HOKURIKU SEIYAKU CO. LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| US-5395832-A | Gastrointestinal disorders | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-07 | — | — | US | disclosed |
| EP-0640601-A1 | BENZAMIDE DERIVATIVE | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |