Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CXCR6 | O00574 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9076217 | 0.90 | DRD2 (0.48) | TSHRCXCR6CXCR4DRD2DRD4 | |
| SCHEMBL9021809 | 0.85 | DRD2 (0.50) | TSHRCXCR6CXCR4DRD2DRD4 | |
| Fumaric Acid SCHEMBL9021486 | 0.83 | DRD2 (0.50) | TSHRCXCR6CXCR4DRD2DRD4 | |
| Fumaric Acid SCHEMBL9021549 | 0.83 | DRD2 (0.50) | TSHRCXCR6CXCR4DRD2DRD4 | |
| SCHEMBL9021504 | 0.83 | DRD2 (0.51) | TSHRCXCR6CXCR4DRD2DRD4 | |
| SCHEMBL9022191 | 0.79 | DRD2 (0.54) | TSHRCXCR6CXCR4DRD2DRD4 | |
| SCHEMBL9021762 | 0.79 | HTR4 (0.51) | DRD2DRD4 | |
| SCHEMBL9021439 | 0.78 | OPRK1 (0.47) | TSHRCXCR6MAPTCXCR4DRD2 | |
| SCHEMBL9021985 | 0.78 | DRD2 (0.52) | TSHRCXCR6CXCR4DRD2DRD4 | |
| SCHEMBL9021950 | 0.78 | DRD2 (0.52) | TSHRCXCR6CXCR4DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640601-B1 | BENZAMIDE DERIVATIVE | HOKURIKU PHARMACEUTICAL (JP) | 1996-12-04 | — | — | EP | disclosed |