Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9075024 | 0.91 | SIGMAR1 (0.66) | KDM4ESIGMAR1MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL9077245 | 0.89 | MEN1 (0.57) | KDM4ESIGMAR1MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL9075949 | 0.83 | HTR1A (0.55) | KDM4EMEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL9074927 | 0.80 | SIGMAR1 (0.82) | KDM4ETDP1TSHRSIGMAR1 | |
| SCHEMBL11365868 | 0.78 | CYP2D6 (0.64) | KDM4ECYP2D6TSHRSIGMAR1 | |
| SCHEMBL9076740 | 0.77 | HPGD (0.53) | — | |
| Oxalic Acid SCHEMBL9077129 | 0.76 | KDM4E (0.58) | KDM4EALDH1A1 | |
| SCHEMBL23926326 | 0.76 | SIGMAR1 (0.79) | CYP2D6TSHRSIGMAR1 | |
| SCHEMBL30118894 | 0.76 | SIGMAR1 (0.79) | CYP2D6TSHRSIGMAR1 | |
| SCHEMBL11372857 | 0.76 | TSHR (0.52) | KDM4ETDP1CYP2D6TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495046-A | PSYCHOLOGICAL DISORDERS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1996-02-27 | — | — | US | disclosed |
| EP-0641766-A1 | ALKOXYPHENYLALKYLAMINE DERIVATIVE | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1995-03-08 | — | — | EP | disclosed |