Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081500 | 0.99 | KMT2A (0.46) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9081462 | 0.86 | KMT2A (0.48) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9080622 | 0.84 | KMT2A (0.46) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9080517 | 0.84 | KMT2A (0.49) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9231591 | 0.83 | PTGES (0.46) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9080899 | 0.83 | ATP4A (0.47) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9081354 | 0.83 | KMT2A (0.48) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9080404 | 0.83 | KMT2A (0.48) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9081886 | 0.83 | KMT2A (0.45) | KMT2AMEN1CRHBPHTTCRHR2 | |
| SCHEMBL9082430 | 0.83 | KMT2A (0.45) | KMT2AMEN1CRHBPHTTCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034866-A1 | IMIDAZO 1,2-A PYRIDINE AND IMIDAZO 1,2-A PYRIDEZINE DERIVATIVES AND THEIR USE AS BONE RESORPTION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-07 | — | — | WO | disclosed |