Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16481851 | 0.79 | HSP90AA1 (0.50) | ALPLMETAP2ALDH1A1GAAHPGD | |
| SCHEMBL9731133 | 0.79 | DCUN1D1 (0.53) | ALPLMETAP2ALDH1A1GAAHPGD | |
| SCHEMBL1408091 | 0.78 | HSP90AA1 (0.53) | METAP2ALDH1A1GAAHPGDMAPT | |
| SCHEMBL11046550 | 0.77 | METAP2 (0.45) | ALPLMETAP2ALDH1A1GAAHPGD | |
| SCHEMBL10825645 | 0.77 | PKM (0.50) | ALPLALDH1A1HSP90AA1DCUN1D1HSP90AB1 | |
| SCHEMBL3932920 | 0.74 | PDGFRB (0.49) | METAP2ALDH1A1GAAHPGDMAPT | |
| SCHEMBL2818901 | 0.72 | SQOR (0.51) | METAP2ALDH1A1GAAHPGDMAPT | |
| SCHEMBL8657051 | 0.72 | HSP90AA1 (0.41) | ALPLMETAP2ALDH1A1GAAHPGD | |
| SCHEMBL4395803 | 0.71 | METAP2 (0.42) | ALPLMETAP2ALDH1A1GAAHPGD | |
| SCHEMBL3629826 | 0.70 | ALDH1A1 (0.57) | METAP2ALDH1A1GAAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |