Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.56 |
| ▸ | LPAR1 | Q92633 | 13/20 | 0.53 |
| ▸ | LPAR5 | Q9H1C0 | 12/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081212 | 0.87 | LPAR1 (0.49) | PTGESLPAR1LPAR5 | |
| SCHEMBL9081270 | 0.86 | LPAR1 (0.63) | PTGESLPAR1LPAR5SRD5A2 | |
| SCHEMBL9080814 | 0.85 | POLB (0.51) | PTGESLPAR1LPAR5SRD5A2 | |
| SCHEMBL9082212 | 0.82 | ALDH1A1 (0.58) | PTGESLPAR1LPAR5SRD5A2 | |
| SCHEMBL9080884 | 0.81 | LPAR1 (0.64) | PTGESLPAR1LPAR5SRD5A2 | |
| SCHEMBL9081179 | 0.81 | PTGES (0.59) | PTGESLPAR1LPAR5SRD5A2NR3C1 | |
| SCHEMBL9080591 | 0.81 | LPAR1 (0.57) | PTGESLPAR1LPAR5 | |
| SCHEMBL9082783 | 0.79 | PTGES (0.79) | PTGES | |
| SCHEMBL9082353 | 0.79 | LPAR1 (0.59) | LPAR1LPAR5 | |
| SCHEMBL9081322 | 0.79 | LPAR1 (0.55) | PTGESLPAR1LPAR5SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |