Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31351864 | 0.79 | FBP1 (0.52) | ALDH1A1RAB9AHPGDNPC1FBP1 | |
| SCHEMBL588852 | 0.77 | FBP1 (0.54) | ALDH1A1HPGDFBP1SMN1; SMN2KDM4E | |
| SCHEMBL30832956 | 0.76 | LMNA (0.57) | ALDH1A1MAP2K2MAP2K1HAO1SMN1; SMN2 | |
| SCHEMBL761802 | 0.76 | LMNA (0.57) | ALDH1A1MAP2K2MAP2K1HAO1SMN1; SMN2 | |
| SCHEMBL11729689 | 0.76 | KCNH2 (0.46) | ALDH1A1NPC1FBP1SMN1; SMN2PDE7A | |
| SCHEMBL9724099 | 0.76 | PDE7A (0.44) | RAB9ANPC1FBP1HAO1SMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL2786811 | 0.75 | FBP1 (0.52) | ALDH1A1HPGDFBP1SMN1; SMN2KDM4E | |
| SCHEMBL2432241 | 0.73 | FBP1 (0.68) | ALDH1A1RAB9AHPGDNPC1FBP1 | |
| SCHEMBL11401871 | 0.73 | SIRT2 (0.43) | ALDH1A1RAB9AHPGDNPC1SIRT2 | |
| SCHEMBL6772507 | 0.72 | FBP1 (0.48) | ALDH1A1RAB9AHPGDNPC1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484805-A | LIPOXYGENASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-01-16 | — | — | US | disclosed |
| EP-0462812-B1 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | disclosed |
| US-5359063-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-10-25 | — | — | US | disclosed |
| US-5217978-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0462812-A2 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |