Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 7/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.65 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.55 |
| ▸ | AGT | P01019 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894 | 0.95 | GP6 (0.62) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9030644 | 0.93 | AGTR2 (0.67) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9029527 | 0.91 | AGTR2 (0.64) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9208011 | 0.89 | AGTR2 (0.64) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9209618 | 0.88 | AGTR2 (0.62) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9594545 | 0.87 | AGTR2 (0.65) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9595666 | 0.87 | AGTR2 (0.58) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9595657 | 0.87 | AGTR2 (0.58) | AGTR2AGTR1GP6AGT | |
| SCHEMBL9030137 | 0.85 | AGTR2 (0.64) | AGTR2AGTR1AGT | |
| SCHEMBL8845227 | 0.85 | AGTR1 (0.64) | AGTR2AGTR1AGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733366-B1 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | DU PONT (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0324377-B1 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | DU PONT (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0733366-A2 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5155118-A | Administering angiotensin inhibitor | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| US-5153197-A | Treatment of hypertension with angiotensin II blocking imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| US-5138069-A | Treating hypertension and congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-11 | — | — | US | disclosed |
| US-5128355-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |
| WO-1989006233-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-13 | — | — | WO | disclosed |