SCHEMBL909285

SCHEMBL909285

[O-][n+]1cccc(C(F)(F)F)c1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 5/20 0.47
TSHR P16473 2/20 0.44
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.38
MAPK1 P28482 1/20 0.35
CFTR P13569 1/20 0.35
S1PR1 P21453 1/20 0.33
KIF11 P52732 1/20 0.33
CES2 O00748 1/20 0.32
MGLL Q99685 1/20 0.32
TDO2 P48775 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29689517 1.00 GPR84 (0.47) GPR84TSHRALDH1A1MEN1KMT2A
SCHEMBL4203234 0.78 GPR84 (0.39) GPR84MEN1KMT2AL3MBTL1
SCHEMBL6552971 0.78 KIF11 (0.55) GPR84S1PR1KIF11
SCHEMBL2616446 0.77 MEN1 (0.41) GPR84ALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL30640907 0.73 TSHR (0.50) TSHRALDH1A1MEN1KMT2AMAPK1
SCHEMBL9478733 0.73 TSHR (0.44) GPR84TSHRALDH1A1MAPK1KIF11
SCHEMBL8735028 0.73 HDAC8 (0.46) TSHRALDH1A1MAPK1KIF11
SCHEMBL26980119 0.73 TSHR (0.44) TSHRALDH1A1MAPK1KIF11CES2
SCHEMBL29644309 0.73 TSHR (0.44) TSHRALDH1A1MAPK1KIF11CES2
SCHEMBL2334903 0.70 S1PR1 (0.53) GPR84TSHRALDH1A1S1PR1KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115784977-A Synthesis process of 2-chloro-3-trifluoromethylpyridine 淄博新农基作物科学有限公司 2023-03-14 CN claimed
EP-2520569-B1 PROCESSES FOR PRODUCING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA (JP) 2014-03-26 EP claimed
EP-2520569-A1 PROCESSES FOR PRODUCING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE Ishihara Sangyo Kaisha, Ltd. (JP) 2012-11-07 EP claimed
US-20120259125-A1 PROCESSES FOR PRODUCING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA, LTD. (JP) 2012-10-11 US claimed
US-20240293383-A1 SUBSTITUTED DIAZASPIROALKANES AS ANDROGEN RECEPTOR MODULATORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2024-09-05 US disclosed
EP-4385574-A2 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES The Regents of the University of California (US) 2024-06-19 EP disclosed
US-11771687-B2 Substituted diazaspiroalkanes as androgen receptor modulators THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-03 US disclosed
EP-2004181-B3 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES UNIV CALIFORNIA (US) 2023-05-24 EP disclosed
CN-115784977-A Synthesis process of 2-chloro-3-trifluoromethylpyridine 淄博新农基作物科学有限公司 2023-03-14 CN disclosed
CN-115784977-A Synthesis process of 2-chloro-3-trifluoromethylpyridine 淄博新农基作物科学有限公司 2023-03-14 CN disclosed
EP-3835294-A1 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES The Regents of The University of California (US) 2021-06-16 EP disclosed
US-20210121450-A1 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-04-29 US disclosed
CN-102712590-A Production method of 2-chloro-3-trifluoromethylpyridine ISHIHARA SANGYO KAISHA 2012-10-03 CN disclosed
EP-2368550-A1 Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases The Regents of The University of California (US) 2011-09-28 EP disclosed
WO-2011078296-A1 PROCESSES FOR PRODUCING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE 石原産業株式会社 (JP) 2011-06-30 WO disclosed
CN-101454002-B Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases UNIV CALIFORNIA 2011-06-08 CN disclosed
US-20110003839-A1 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-06 US disclosed
CN-101454002-A Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases UNIV CALIFORNIA (US) 2009-06-10 CN disclosed
US-20050075375-A1 Heterocyclic compounds for treating hepatitis C virus ANADYS PHARMACEUTICALS, INC. (US) 2005-04-07 US disclosed
WO-2004110351-A2 HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS ANADYS PHARMACEUTICALS, INC. (US) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121450-A1 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES AR, ESRRA, NR5A1 GPR84 407/4885TSHR 1273/4885ALDH1A1 1411/4885
US-20120259125-A1 PROCESSES FOR PRODUCING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE CBR3, TH, CBR1 GPR84 4199/4885TSHR 2012/4885ALDH1A1 1163/4885
US-20240293383-A1 SUBSTITUTED DIAZASPIROALKANES AS ANDROGEN RECEPTOR MODULATORS AR, HRAS, NR5A1 GPR84 146/4885TSHR 1811/4885ALDH1A1 498/4885
US-11771687-B2 Substituted diazaspiroalkanes as androgen receptor modulators AR, HRAS, NR5A1 GPR84 146/4885TSHR 1811/4885ALDH1A1 498/4885
US-20050075375-A1 Heterocyclic compounds for treating hepatitis C virus HAVCR2, HCCS, LIPC GPR84 928/4885TSHR 4398/4885ALDH1A1 287/4885
US-20110003839-A1 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES AR, NR5A1, SHBG GPR84 85/4885TSHR 1791/4885ALDH1A1 991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.