Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30931514 | 1.00 | CA12 (0.31) | CA12CA1CA2CA9CYP1A2 | |
| SCHEMBL2035350 | 1.00 | CA12 (0.31) | CA12CA1CA2CA9CYP1A2 | |
| SCHEMBL2518471 | 0.74 | TDP2 (0.37) | CA12CA1CA2CA9CYP1A2 | |
| SCHEMBL30047476 | 0.68 | — | — | |
| SCHEMBL1762427 | 0.68 | NPC1 (0.35) | CYP1A2SMN1; SMN2 | |
| SCHEMBL5530115 | 0.67 | NPC1 (0.40) | CYP1A2SMN1; SMN2 | |
| SCHEMBL924457 | 0.67 | OTUD7B (0.31) | CA12CA1CA2CA9 | |
| SCHEMBL16430005 | 0.67 | CA12 (0.30) | CA12CA1CA2CA9 | |
| SCHEMBL924702 | 0.67 | CA12 (0.30) | CA12CA1CA2CA9 | |
| SCHEMBL224635 | 0.66 | ALOX5 (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701560-A1 | BICYCLIC ETHER DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1995030668-A1 | CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ZENECA LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |
| WO-1994027999-A1 | BICYCLIC ETHER DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-12-08 | — | — | WO | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |