Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459588 | 0.89 | KDR (0.44) | KDRFLT1ROCK2 | |
| SCHEMBL9098841 | 0.89 | KDR (0.41) | KDRFLT1ROCK2HDAC1 | |
| SCHEMBL9103231 | 0.83 | KDR (0.42) | KDRFLT1 | |
| SCHEMBL9100015 | 0.82 | KDR (0.38) | KDRTEKEGFR | |
| SCHEMBL5724634 | 0.81 | KDR (0.40) | KDRFLT1ROCK2HDAC1 | |
| SCHEMBL4473222 | 0.77 | KDR (0.44) | KDRFLT1ROCK2HDAC1 | |
| SCHEMBL9103055 | 0.77 | LMNA (0.44) | KDR | |
| SCHEMBL9099762 | 0.76 | KDR (0.42) | KDR | |
| SCHEMBL9102033 | 0.76 | LCLAT1 (0.42) | KDR | |
| SCHEMBL9102036 | 0.76 | MAPT (0.41) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |