Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725077 | 0.93 | KDR (0.41) | KDRFLT1MEN1KMT2ARAF1 | |
| SCHEMBL9098841 | 0.91 | KDR (0.41) | KDRFLT1 | |
| SCHEMBL4470743 | 0.89 | KDR (0.45) | KDRFLT1RAF1 | |
| SCHEMBL5724634 | 0.84 | KDR (0.40) | KDRFLT1MEN1KMT2A | |
| SCHEMBL9100306 | 0.83 | KDR (0.41) | KDRFLT1 | |
| SCHEMBL9102033 | 0.82 | LCLAT1 (0.42) | KDRMEN1KMT2A | |
| SCHEMBL9104786 | 0.81 | RAF1 (0.49) | KDRRAF1 | |
| SCHEMBL9103055 | 0.81 | LMNA (0.44) | KDRMEN1KMT2ARAF1 | |
| SCHEMBL9102036 | 0.80 | MAPT (0.41) | KDRMEN1KMT2A | |
| SCHEMBL4473222 | 0.80 | KDR (0.44) | KDRFLT1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |