⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668929 | 0.77 | — | — | |
| SCHEMBL3973912 | 0.64 | — | — | |
| SCHEMBL14688081 | 0.62 | — | — | |
| SCHEMBL6624467 | 0.58 | NPC1 (0.30) | — | |
| SCHEMBL1706932 | 0.57 | HDAC6 (0.38) | — | |
| SCHEMBL3361720 | 0.56 | HDAC6 (0.35) | — | |
| SCHEMBL12812508 | 0.56 | TSHR (0.33) | — | |
| SCHEMBL9101239 | 0.55 | MTNR1A (0.33) | — | |
| SCHEMBL4514786 | 0.55 | ALDH1A1 (0.43) | — | |
| SCHEMBL5737167 | 0.54 | MAPT (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342440-A1 | Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System | INTREXON CORP (US) | 2017-11-30 | — | — | US | disclosed |
| EP-3219204-A1 | MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM | Intrexon Corporation (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2460786-B1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORP (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2292088-B1 | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system | INTREXON CORP (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20120185954-A1 | Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression | INTREXON CORPORATION (US) | 2012-07-19 | — | — | US | disclosed |
| EP-2460786-A1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | Intrexon Corporation (US) | 2012-06-06 | — | — | EP | disclosed |