Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514786 | 0.70 | ALDH1A1 (0.43) | SMN1; SMN2HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL5737167 | 0.69 | MAPT (0.42) | NPC1SMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL1706932 | 0.69 | HDAC6 (0.38) | SMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL6529111 | 0.69 | GPR119 (0.46) | SMN1; SMN2HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL6501523 | 0.69 | DAO (0.40) | HDAC3HDAC1 | |
| SCHEMBL6624469 | 0.69 | GAA (0.40) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1401073 | 0.67 | PARP1 (0.46) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7362268 | 0.67 | HPGD (0.44) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL5908845 | 0.66 | POLB (0.46) | — | |
| SCHEMBL25436784 | 0.65 | AAK1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487827-A1 | ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | claimed |
| WO-2003082862-A1 | ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | claimed |
| EP-1487827-A1 | ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082862-A1 | ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |