Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737167 | 0.88 | MAPT (0.42) | ALDH1A1TSHRPOLBHDAC3HDAC1 | |
| SCHEMBL30616197 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10TDP1POLB | |
| SCHEMBL1401073 | 0.82 | PARP1 (0.46) | ALDH1A1TSHRTDP1POLBSLC7A5 | |
| SCHEMBL29277587 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TSHRHSD17B10TDP1HDAC1 | |
| SCHEMBL6529111 | 0.81 | GPR119 (0.46) | SLC7A5HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL21470599 | 0.81 | CYP1A2 (0.46) | ALDH1A1TSHRHSD17B10TDP1POLB | |
| SCHEMBL5170962 | 0.80 | TSHR (0.50) | ALDH1A1TSHRTDP1POLBHDAC1 | |
| SCHEMBL25984799 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TSHRHSD17B10TDP1POLB | |
| SCHEMBL8779784 | 0.78 | L3MBTL1 (0.47) | ALDH1A1TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5908845 | 0.78 | POLB (0.46) | TSHRPOLBCYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724325-A1 | CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING | Codexis, Inc. (US) | 2020-10-21 | — | — | EP | claimed |
| WO-2019118557-A1 | CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING | CODEXIS, INC. (US) | 2019-06-20 | — | — | WO | claimed |
| EP-3724325-A1 | CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING | Codexis, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |
| WO-2020077459-A1 | AMINOBENZOIC ACID DERIVATIVES FOR USE AS ANTI-INFLAMMATORY AGENTS, ANTI-METASTATIC AGENTS AND/OR ANTICANCER AGENTS | 3R VALO, S.E.C. (CA) | 2020-04-23 | — | — | WO | disclosed |
| WO-2019118557-A1 | CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING | CODEXIS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |
| US-7582627-B2 | 3-Amino-7-[3-(1-aminoethyl)-4-fluoropyrrolidin-1-yl]-1-cyclopropyl-8-methyl-1H-pyrido[4,3-d]pyrimidine-2,4-dione; quinolone antibiotics; bactericides; for antibiotic- resistant bacterial infections, ciprofloxacin- resistant ones; inhibiting wild-type and quinolone- resistant mutants of DNA gryase | WARNER-LAMBERT COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| EP-1255739-B1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20060287308-A1 | 3-Aminoquinazolin-2,4-dione antibacterial agents | ZOETIS WLC LLC | 2006-12-21 | — | — | US | disclosed |
| US-7094780-B1 | 3-aminoquinazolin-2,4-dione antibacterial agents | WARNER LAMBERT COMPANY LLC (US) | 2006-08-22 | — | — | US | disclosed |
| US-20060183762-A1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | ZOETIS WLC LLC | 2006-08-17 | — | — | US | disclosed |
| EP-1255739-A1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001053273-A1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183762-A1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | ABL1, NQO2, CBR3 | ALDH1A1 2259/4885TSHR 1500/4885HSD17B10 2598/4885 |
| US-20060287308-A1 | 3-Aminoquinazolin-2,4-dione antibacterial agents | ABL1, NQO2, AAAS | ALDH1A1 2203/4885TSHR 1599/4885HSD17B10 2568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.