Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.36 |
| ▸ | ITGAL | P20701 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SDCBP | O00560 | 1/20 | 0.31 |
| ▸ | SDC2 | P34741 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105786 | 0.92 | GPBAR1 (0.33) | LMNAITGB2ICAM1ITGALMEN1 | |
| SCHEMBL9099926 | 0.90 | HDAC1 (0.32) | ITGB2ICAM1ITGALGPBAR1MAPT | |
| SCHEMBL3702422 | 0.88 | GPBAR1 (0.35) | ITGB2ICAM1ITGALGPBAR1HDAC1 | |
| SCHEMBL9105245 | 0.88 | ALDH1A1 (0.41) | LMNAKMT2AMAPTTP53KDM4E | |
| SCHEMBL3701709 | 0.87 | HPGD (0.40) | LMNAMEN1KMT2AGPBAR1MAPT | |
| SCHEMBL3701796 | 0.87 | MEN1 (0.35) | LMNAMEN1KMT2AMAPTHDAC1 | |
| SCHEMBL3699232 | 0.85 | ALDH1A1 (0.38) | LMNASMN1; SMN2MEN1KMT2AGPBAR1 | |
| SCHEMBL9104212 | 0.85 | ALDH1A1 (0.40) | LMNAMEN1KMT2AMAPTPOLB | |
| SCHEMBL9103931 | 0.84 | ITGB2 (0.44) | LMNASMN1; SMN2ITGB2ICAM1ITGAL | |
| SCHEMBL9107195 | 0.83 | MEN1 (0.41) | SMN1; SMN2MEN1KMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460798-A2 | APAF-1 INHIBITOR COMPOUNDS | Laboratorios SALVAT, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |