Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104212 | 0.97 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL9105786 | 0.91 | GPBAR1 (0.33) | ALDH1A1MAPTKDM4ELMNATP53 | |
| SCHEMBL3702498 | 0.91 | HPGD (0.39) | ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL9104473 | 0.88 | LMNA (0.39) | MAPTKDM4ELMNATP53KMT2A | |
| SCHEMBL3701709 | 0.88 | HPGD (0.40) | ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL3701796 | 0.88 | MEN1 (0.35) | ALDH1A1MAPTKDM4ELMNAHSD17B10 | |
| SCHEMBL9099926 | 0.87 | HDAC1 (0.32) | MAPT | |
| SCHEMBL3700736 | 0.86 | BCHE (0.45) | ALDH1A1MAPTKDM4ETSHRHSD17B10 | |
| SCHEMBL3702422 | 0.86 | GPBAR1 (0.35) | ALDH1A1TP53TSHR | |
| SCHEMBL9106131 | 0.85 | KMT2A (0.41) | ALDH1A1KDM4ELMNAHSD17B10LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460798-A2 | APAF-1 INHIBITOR COMPOUNDS | Laboratorios SALVAT, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |