Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283371 | 0.88 | PPARG (0.51) | HDAC8HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL10318265 | 0.87 | ALDH1A1 (0.50) | LMNANPSR1ALDH1A1POLBMAPT | |
| SCHEMBL11982645 | 0.85 | HDAC1 (0.46) | HDAC8HDAC1HDAC6 | |
| SCHEMBL20865561 | 0.84 | ALDH1A1 (0.56) | CA12CA1CA9CYP17A1NPC1 | |
| SCHEMBL13495792 | 0.84 | LCK (0.40) | CA12CA1CA9HDAC8CYP17A1 | |
| SCHEMBL4568018 | 0.84 | NLRP3 (0.55) | HDAC8HDAC1HDAC6RAB9ASMN1; SMN2 | |
| SCHEMBL24661913 | 0.84 | CYP17A1 (0.51) | CA12CA1CA9HDAC8CYP17A1 | |
| SCHEMBL16385178 | 0.84 | ALDH1A1 (0.52) | HDAC8CYP17A1HDAC1HDAC6NPC1 | |
| SCHEMBL28294971 | 0.83 | RAB9A (0.50) | CA12CA1CA9NPC1RAB9A | |
| SCHEMBL14738934 | 0.82 | GAA (0.43) | CA12CA1CA9HDAC8CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563558-B2 | Substituted pyridine urea compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| WO-2012078673-A1 | SUBSTITUTED PYRIDINE UREA COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-20120142708-A1 | SUBSTITUTED PYRIDINE UREA COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142708-A1 | SUBSTITUTED PYRIDINE UREA COMPOUNDS | MAPK1, MAP3K1, MAP3K8 | CA12 4825/4885CA1 4782/4885CA9 4734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.