Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31697821 | 0.90 | KDM4E (0.47) | ALDH1A1KDM4EL3MBTL1MAPTCYP2C9 | |
| SCHEMBL11959276 | 0.88 | LCK (0.49) | ALDH1A1KDM4EMAPTLCKGLA | |
| SCHEMBL16318447 | 0.88 | KDM4E (0.52) | ALDH1A1KDM4EL3MBTL1LCKGLA | |
| SCHEMBL28294971 | 0.87 | RAB9A (0.50) | ALDH1A1LMNAGAA | |
| SCHEMBL9104625 | 0.87 | CA12 (0.44) | ALDH1A1MAPTLMNANPSR1POLB | |
| SCHEMBL2283371 | 0.87 | PPARG (0.51) | ALDH1A1KDM4EL3MBTL1MAPTLMNA | |
| SCHEMBL2934675 | 0.85 | CA12 (0.54) | ALDH1A1KDM4EL3MBTL1MAPTCYP2C9 | |
| SCHEMBL4490699 | 0.84 | KDM4E (0.49) | ALDH1A1KDM4EL3MBTL1MAPTLMNA | |
| SCHEMBL29281561 | 0.84 | KDM4E (0.49) | ALDH1A1KDM4EL3MBTL1MAPTLMNA | |
| SCHEMBL31480211 | 0.84 | KDM4E (0.49) | ALDH1A1KDM4EL3MBTL1LCKGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152287-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | UNIVERSITY OF ROCHESTER | 2017-06-01 | — | — | US | disclosed |
| US-9557336-B2 | Methods and compositions for site-specific labeling of peptides and proteins | UNIVERSITY OF ROCHESTER (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150241440-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | NATIONAL SCIENCE FOUNDATION | 2015-08-27 | — | — | US | disclosed |
| EP-2892929-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | University Of Rochester (US) | 2015-07-15 | — | — | EP | disclosed |
| EP-2665744-B1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIV ROCHESTER (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | disclosed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | disclosed |
| WO-2014039715-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | UNIVERSITY OF ROCHESTER (US) | 2014-03-13 | — | — | WO | disclosed |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | NATIONAL SCIENCE FOUNDATION | 2013-12-12 | — | — | US | disclosed |
| EP-2665744-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012100176-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | DOMINIQUE ROMYR (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | DOMINIQUE ROMYR (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | DOMINIQUE ROMYR (US) | 2012-07-19 | — | — | US | disclosed |
| EP-1562949-B1 | METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-12-30 | — | — | EP | disclosed |
| US-7211666-B2 | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152287-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | PTMS, ACP1, QPCTL | ALDH1A1 3945/4885KDM4E 3959/4885L3MBTL1 748/4885 |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | MICA, VIP, NPEPPS | ALDH1A1 4832/4885KDM4E 4356/4885L3MBTL1 1096/4885 |
| US-20150241440-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | PTMS, ACP1, QPCTL | ALDH1A1 3945/4885KDM4E 3959/4885L3MBTL1 748/4885 |
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | GOT1, PPARG, PPARA | ALDH1A1 62/4885KDM4E 1393/4885L3MBTL1 4430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.