Methane

Methane

SCHEMBL9104929

C.Cc1cccc(C2CCCCC2)c1O

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.46
HTR2C P28335 4/20 0.43
TRPA1 O75762 1/20 0.42
FEN1 P39748 3/20 0.41
PTPN5 P54829 3/20 0.40
PTPN2 P17706 1/20 0.40
ALOX12 P18054 1/20 0.38
EPHX1 P07099 1/20 0.38
ALOX5AP P20292 2/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.37
GABRA1 P14867 1/20 0.37
GABRB2 P47870 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30218222 0.98 ALDH1A1 (0.48) ALDH1A1HTR2CTRPA1FEN1PTPN5
SCHEMBL8954630 0.98 ALDH1A1 (0.48) ALDH1A1HTR2CTRPA1FEN1PTPN5
SCHEMBL673222 0.98 ALDH1A1 (0.48) ALDH1A1HTR2CTRPA1FEN1PTPN5
SCHEMBL466853 0.96 ALDH1A1 (0.50) ALDH1A1HTR2CTRPA1FEN1PTPN5
SCHEMBL930208 0.88 ALDH1A1 (0.54) ALDH1A1HTR2CTRPA1GABRA1GABRB2
SCHEMBL27936382 0.88 PTPN5 (0.46) ALDH1A1HTR2CTRPA1FEN1PTPN5
SCHEMBL27857366 0.86 ALDH1A1 (0.52) ALDH1A1HTR2CTRPA1GABRA1GABRB2
SCHEMBL23854308 0.85 ADRA2A (0.41) ALDH1A1HTR2CTRPA1FEN1PTPN5
SCHEMBL4958862 0.84 PTPN5 (0.46) FEN1PTPN5PTPN2ALOX5APPTGDR2
SCHEMBL4958978 0.84 PTPN5 (0.46) FEN1PTPN5PTPN2ALOX5APPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2904032-A2 METHODS OF MANUFACTURE OF BIS(PHTHALIMIDE)S AND POLYETHERIMIDES, AND BIS(PHTHALIMIDE)S, AND POLYETHERIMIDES FORMED THEREFROM SABIC Global Technologies B.V. (NL) 2015-08-12 EP disclosed
EP-2771384-A1 POLYETHERIMIDES, METHODS OF MANUFACTURE, AND ARTICLES FORMED THEREFROM SABIC Innovative Plastics IP B.V. (NL) 2014-09-03 EP disclosed
WO-2014055856-A2 METHODS OF MANUFACTURE OF BIS(PHTHALIMIDE)S AND POLYETHERIMIDES, AND BIS(PHTHALIMIDE)S, AND POLYETHERIMIDES FORMED THEREFROM SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-04-10 WO disclosed
WO-2013066757-A1 POLYETHERIMIDES, METHODS OF MANUFACTURE, AND ARTICLES FORMED THEREFROM SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2013-05-10 WO disclosed
EP-2459577-A1 LIQUID ALKYLATED TRISARYL PHOSPHITE COMPOSITIONS HAVING TWO ALKYL GROUPS WITH DIFFERENT CARBON NUMBER Chemtura Corporation (US) 2012-06-06 EP disclosed