Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107481 | 0.69 | — | — | |
| SCHEMBL512796 | 0.68 | HRH3 (0.33) | HRH2HRH3 | |
| SCHEMBL11791725 | 0.64 | HCAR2 (0.30) | HCAR2 | |
| Propylene Oxide SCHEMBL6866878 | 0.62 | LMNA (0.35) | HRH2HRH3 | |
| SCHEMBL1226524 | 0.59 | KDM4E (0.37) | — | |
| SCHEMBL4424819 | 0.58 | HRH3 (0.44) | HRH2HRH3 | |
| SCHEMBL28877816 | 0.56 | DHFR (0.41) | HRH2HRH3 | |
| SCHEMBL7940046 | 0.54 | ADORA2A (0.48) | ADORA2A | |
| SCHEMBL31041484 | 0.53 | KDM4E (0.33) | — | |
| SCHEMBL10049719 | 0.52 | LMNA (0.39) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459197-A1 | COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-06-06 | — | — | EP | claimed |