SCHEMBL9108150

SCHEMBL9108150

C#Cc1cccc(C(=O)OC)c1C(=O)OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA9 Q16790 2/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA14 Q9ULX7 1/20 0.48
LMNA P02545 1/20 0.46
TSHR P16473 1/20 0.46
ALDH1A1 P00352 1/20 0.44
CFTR P13569 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KDM4E B2RXH2 2/20 0.43
POLB P06746 1/20 0.43
ATM Q13315 1/20 0.43
NR4A2 P43354 4/20 0.42
CA5A P35218 1/20 0.40
MAPT P10636 1/20 0.40
ALOX15 P16050 1/20 0.40
KMT2A Q03164 1/20 0.40
ALOX5 P09917 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8015094 0.86 SLC6A3 (0.42) CA1CA2CA9CA12CA7
SCHEMBL8834011 0.84 CA1 (0.50) CA1CA2CA9CA12CA7
SCHEMBL498003 0.84 TSHR (0.55) CA1CA2CA9LMNATSHR
SCHEMBL2383149 0.83 CA12 (0.48) CA1CA2CA9CA12CA7
SCHEMBL25044297 0.83 LMNA (0.46) CA1CA2CA9CA12CA7
Benzene SCHEMBL28861660 0.81 LMNA (0.44) CA1CA2CA9CA12CA7
SCHEMBL29628477 0.81 PDK1 (0.45) CA1CA2CA9CA12CA7
SCHEMBL16719514 0.81 ALDH1A1 (0.51) CA1CA2CA9CA12CA7
SCHEMBL16719456 0.81 TSHR (0.44) CA1CA2CA9CA12CA7
SCHEMBL24626055 0.81 TSHR (0.44) CA1CA2CA9CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1586569-B1 Aryl ethynyl phthalic acid derivative and method for producing the same FUJIFILM CORP (JP) 2012-06-06 EP disclosed