Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109335 | 0.86 | ALDH1A1 (0.40) | MRGPRX4DAPK1PIM3KDM4EALDH1A1 | |
| SCHEMBL20515885 | 0.84 | TSHR (0.53) | MRGPRX4DAPK1PIM3KDM4EALDH1A1 | |
| SCHEMBL6563613 | 0.84 | KDM4E (0.64) | MRGPRX4DAPK1PIM3KDM4EALDH1A1 | |
| SCHEMBL2831563 | 0.84 | HPGD (0.43) | KDM4EALDH1A1HPGDTDP1MEN1 | |
| SCHEMBL6959477 | 0.83 | MRGPRX4 (0.66) | MRGPRX4ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30696120 | 0.83 | MRGPRX4 (0.66) | MRGPRX4ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL20515855 | 0.81 | MRGPRX4 (0.46) | MRGPRX4DAPK1PIM3KDM4EALDH1A1 | |
| SCHEMBL8089490 | 0.80 | PLA2G2A (0.52) | ALDH1A1HPGD | |
| SCHEMBL20515873 | 0.80 | PDE4B (0.46) | MRGPRX4DAPK1PIM3KDM4EALDH1A1 | |
| SCHEMBL13132193 | 0.80 | MRGPRX4 (0.45) | MRGPRX4DAPK1PIM3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575454-A1 | NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011159067-A2 | THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN CROSS CORPORATION (KR) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011149801-A1 | NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-1995010504-A1 | 2-(1-ALKOXY-2-NAPHTHALENYL)-PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-04-20 | — | — | WO | disclosed |