Sugi Predict

Sugi Predict / Compounds / SCHEMBL910959

SCHEMBL910959

SCHEMBL910959

O=[N+]([O-])c1c(Cl)ccnc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.44
▸ KMT2A Q03164 6/20 0.44
▸ ALDH1A1 P00352 6/20 0.44
▸ KDM4E B2RXH2 4/20 0.44
▸ TDP1 Q9NUW8 3/20 0.44
▸ MAPT P10636 3/20 0.43
▸ PKM P14618 2/20 0.43
▸ HTT P42858 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ HSP90AA1 P07900 2/20 0.43
▸ LMNA P02545 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ OPRK1 P41145 1/20 0.43
▸ TSHR P16473 2/20 0.41
▸ CTSB P07858 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ IDO1 P14902 1/20 0.37
▸ TDO2 P48775 1/20 0.37
▸ GRIN2D O15399 3/20 0.36
▸ GRIN3B O60391 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29534703 1.00 MEN1 (0.44) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL31571463 0.80 GPR35 (0.47) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL1191637 0.80 GPR35 (0.47) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL29467174 0.80 ALDH1A1 (0.46) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL202927 0.80 ALDH1A1 (0.46) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL2972185 0.77 ALDH1A1 (0.44) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL29658100 0.77 HTT (0.45) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL783847 0.77 HTT (0.45) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL28051802 0.77 ALDH1A1 (0.44) MEN1KMT2AALDH1A1KDM4ETDP1
SCHEMBL4064206 0.77 MEN1 (0.41) MEN1KMT2AALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108498516-A A kind of pharmaceutical composition and its preparation method and application for treating myocardial damage 王洁 2018-09-07 — — CN claimed
US-20250236621-A1 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ENLIVEN INC. 2025-07-24 — — US disclosed
US-12344623-B2 Thiazolopyridine derivatives as adenosine receptor antagonists DOMAIN THERAPEUTICS SA (FR) 2025-07-01 — — US disclosed
EP-4522618-A1 TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS Merck Patent GmbH (DE) 2025-03-19 — — EP disclosed
US-12240846-B2 5- and 6-azaindole compounds for inhibition of Bcr-Abl tyrosine kinases ENLIVEN INC. (US) 2025-03-04 — — US disclosed
CN-119019388-A 5-And 6-azaindole compounds for inhibiting Bcr-Abl tyrosine kinase 英莱汶公司 2024-11-26 — — CN disclosed
CN-113939520-B Thiazolopyridine derivatives as adenosine receptor antagonists 默克专利股份公司 2024-11-22 — — CN disclosed
EP-3914600-B1 THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS MERCK PATENT GMBH (DE) 2024-08-07 — — EP disclosed
US-20240043420-A1 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ENLIVEN INC. 2024-02-08 — — US disclosed
US-20240025922-A1 TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS MERCK HEALTHCARE KGAA (DE) 2024-01-25 — — US disclosed
US-20070112019-A1 9-Azabicyclo[3.3.1]nonane derivatives N.V. ORGANON (NL) 2007-05-17 — — US disclosed
US-20070112019-A1 9-Azabicyclo[3.3.1]nonane derivatives N.V. ORGANON (NL) 2007-05-17 — — US disclosed
WO-2007039563-A1 9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS N.V. ORGANON (NL) 2007-04-12 — — WO disclosed
WO-2007039563-A1 9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS N.V. ORGANON (NL) 2007-04-12 — — WO disclosed
EP-1117660-A4 THROMBIN INHIBITORS MERCK & CO INC (US) 2002-01-09 — — EP disclosed
EP-1117660-A1 THROMBIN INHIBITORS Merck & Co., Inc. (US) 2001-07-25 — — EP disclosed
US-6117888-A N-((2-AMINO-6-METHYLPYRID-5YL)METHYLAMINOCARBONYLMETHYL)PYRIDO NE-4-SULFONAMIDES MERCK & CO., INC. (US) 2000-09-12 — — US disclosed
WO-2000018762-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 2000-04-06 — — WO disclosed
US-4256741-A INSECTICIDES, MITICIDES, APHIDICIDES VELSICOL CHEMICAL CORPORATION (US) 1981-03-17 — — US disclosed
US-4226859-A INSECTICIDES VELSICOL CHEMICAL CORPORATION (US) 1980-10-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12344623-B2 Thiazolopyridine derivatives as adenosine receptor antagonists ADORA1, ADORA2A, ADORA3 MEN1 2872/4885KMT2A 4293/4885ALDH1A1 233/4885
US-20250236621-A1 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ABL1, ABL2, BCR MEN1 4209/4885KMT2A 450/4885ALDH1A1 1397/4885
US-20240043420-A1 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ABL1, ABL2, BCR MEN1 4375/4885KMT2A 411/4885ALDH1A1 1355/4885
US-20240025922-A1 TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS PDXK, DTYMK, HIPK1 MEN1 2978/4885KMT2A 2685/4885ALDH1A1 3576/4885
US-12240846-B2 5- and 6-azaindole compounds for inhibition of Bcr-Abl tyrosine kinases ABL1, ABL2, BCR MEN1 4209/4885KMT2A 450/4885ALDH1A1 1397/4885
US-20070112019-A1 9-Azabicyclo[3.3.1]nonane derivatives AZI2, TPMT, TET3 MEN1 1510/4885KMT2A 844/4885ALDH1A1 441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.