Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768643 | 0.83 | ALDH1A1 (0.46) | PPARAPPARGLMNAALDH1A1ATM | |
| SCHEMBL24177870 | 0.72 | PPARA (0.59) | PPARAPPARGHTTFBP1CYP1A2 | |
| SCHEMBL8768838 | 0.67 | PPARA (0.48) | PPARAPPARGFBP1CYP1A2ABCB11 | |
| SCHEMBL8767912 | 0.67 | SOAT1 (0.48) | PPARAPPARGFBP1SOAT1 | |
| SCHEMBL8768939 | 0.66 | PPARA (0.45) | PPARAPPARGLMNAALDH1A1RAB9A | |
| SCHEMBL7981279 | 0.65 | FBP1 (0.54) | PPARAPPARGALDH1A1FBP1CYP1A2 | |
| SCHEMBL8768856 | 0.65 | SOAT1 (0.52) | PPARAPPARGLMNAALDH1A1RAB9A | |
| SCHEMBL7328337 | 0.65 | GPR35 (0.62) | LMNAALDH1A1RAB9ANPC1HTT | |
| SCHEMBL8925558 | 0.64 | PPARA (0.40) | PPARAPPARGALDH1A1FBP1KDM4E | |
| SCHEMBL8768601 | 0.64 | PPARG (0.70) | PPARAPPARGHTTMAPTSOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. | WELLCOME FOUND (GB) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992010468-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |