Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322003 | 0.82 | POLB (0.66) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL293402 | 0.80 | POLB (0.72) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL230157 | 0.79 | POLB (0.84) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL833457 | 0.79 | POLB (0.66) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL9302629 | 0.79 | POLB (0.66) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL28706592 | 0.78 | POLB (0.70) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL293269 | 0.77 | POLB (0.79) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL291451 | 0.76 | DDAH1 (0.66) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL7006523 | 0.76 | POLB (1.00) | POLBNPC1RAB9ADDAH1CHRM1 | |
| SCHEMBL7854448 | 0.76 | POLB (0.92) | POLBNPC1RAB9ADDAH1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |