SCHEMBL9114032

SCHEMBL9114032

Nc1ccc(C#CC#Cc2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.69
KMT2A Q03164 6/20 0.56
MEN1 O00255 5/20 0.56
MAPT P10636 5/20 0.56
CASP3 P42574 1/20 0.56
SENP8 Q96LD8 1/20 0.56
SENP7 Q9BQF6 1/20 0.56
SENP6 Q9GZR1 1/20 0.56
ESR1 P03372 2/20 0.49
CYP19A1 P11511 2/20 0.49
ESR2 Q92731 2/20 0.49
APP P05067 1/20 0.48
PKM P14618 1/20 0.46
HSP90AA1 P07900 1/20 0.42
OPRK1 P41145 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5959613 0.92 ALDH1A1 (0.75) ALDH1A1KMT2AMEN1MAPTCASP3
SCHEMBL19929693 0.86 CASP3 (0.53) ALDH1A1KMT2AMEN1MAPTCASP3
4-Nitroaniline SCHEMBL16451 0.83 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1MAPTESR1
4-Nitroaniline SCHEMBL27963818 0.83 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1MAPTESR1
4-Nitroaniline SCHEMBL13529022 0.83 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1MAPTESR1
SCHEMBL9065915 0.83 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1MAPTESR1
4-Nitroaniline SCHEMBL7158091 0.81 ALDH1A1 (0.95) ALDH1A1KMT2AMEN1MAPTESR1
SCHEMBL14664048 0.81 CASP3 (0.63) ALDH1A1KMT2AMEN1MAPTCASP3
4-Nitroaniline SCHEMBL21825602 0.81 ALDH1A1 (0.95) ALDH1A1KMT2AMEN1MAPTESR1
4-Nitroaniline SCHEMBL7158084 0.81 ALDH1A1 (0.95) ALDH1A1KMT2AMEN1MAPTESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995015009-A1 POROUS CRYSTALLINE MATERIALS HAVING NONLINEAR OPTICAL PROPERTIES MOBIL OIL CORPORATION (US) 1995-06-01 WO disclosed
US-5348687-A M41S materials having nonlinear optical properties MOBIL OIL CORP. (US) 1994-09-20 US disclosed