SCHEMBL9114963

SCHEMBL9114963

Nc1ccc(C(=O)c2cccc(C(=O)c3ccc(N)c(O)c3)c2)cc1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.54
ATM Q13315 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
FASN P49327 1/20 0.52
PBRM1 Q86U86 1/20 0.50
LMNA P02545 2/20 0.47
NPC1 O15118 1/20 0.47
MITF O75030 1/20 0.47
POLB P06746 1/20 0.47
CLK1 P49759 1/20 0.46
DYRK1A Q13627 1/20 0.46
DYRK1B Q9Y463 1/20 0.46
STS P08842 4/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
CNR2 P34972 1/20 0.45
CYP3A4 P08684 1/20 0.45
ALOX15 P16050 1/20 0.45
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL766129 0.92 HSD17B10 (0.52) L3MBTL1FASNPBRM1LMNANPC1
SCHEMBL29412590 0.92 HSD17B10 (0.52) L3MBTL1FASNPBRM1LMNANPC1
SCHEMBL4608574 0.90 PBRM1 (0.58) L3MBTL1ATMTDP1PBRM1LMNA
SCHEMBL6853626 0.84 GAA (0.47) L3MBTL1FASNLMNANPC1POLB
SCHEMBL9328747 0.82 SRD5A2 (0.58) L3MBTL1TDP1POLBCA1CA2
SCHEMBL180385 0.77 KDM4E (0.64) L3MBTL1TDP1LMNAPOLBCA1
SCHEMBL5595306 0.77 LCK (0.55) L3MBTL1POLBCA1CA2CA9
SCHEMBL203108 0.77 PBRM1 (0.67) L3MBTL1ATMTDP1PBRM1LMNA
SCHEMBL21369269 0.77 ALDH1A1 (0.58) L3MBTL1TDP1LMNANPC1STS
SCHEMBL9306191 0.75 KDM4E (0.61) L3MBTL1TDP1LMNAPOLBCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623115-A4 NUCLEOPHILIC DISPLACEMENT METHOD FOR SYNTHESIS OF NON-RIGID PBZ POLYMERS. DOW CHEMICAL CO (US) 1995-01-11 EP disclosed
EP-0623115-A1 NUCLEOPHILIC DISPLACEMENT METHOD FOR SYNTHESIS OF NON-RIGID PBZ POLYMERS THE DOW CHEMICAL COMPANY (US) 1994-11-09 EP disclosed
WO-1993014071-A1 NUCLEOPHILIC DISPLACEMENT METHOD FOR SYNTHESIS OF NON-RIGID PBZ POLYMERS THE DOW CHEMICAL COMPANY (US) 1993-07-22 WO disclosed
US-5216110-A Monomers useful in nucleophilic displacement synthesis of polybenzazole polymers THE DOW CHEMICAL COMPANY (US) 1993-06-01 US disclosed
US-5194562-A Nucleophilic displacement method for synthesis of non-rigid PBZ polymers THE DOW CHEMICAL COMPANY (US) 1993-03-16 US disclosed
US-5104960-A Nucleophilic displacement method for synthesis of non-rigid PBZ polymers THE DOW CHEMICAL COMPANY (US) 1992-04-14 US disclosed