Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.65 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118004 | 0.90 | PTGS2 (0.64) | PTGS2PTGS1KIF11 | |
| SCHEMBL9119695 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1KIF11 | |
| SCHEMBL9117392 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1KIF11 | |
| SCHEMBL9117493 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1KIF11 | |
| SCHEMBL9116462 | 0.88 | KIF11 (0.52) | PTGS2PTGS1KIF11 | |
| SCHEMBL9118144 | 0.86 | PTGS2 (0.62) | PTGS2PTGS1KIF11 | |
| SCHEMBL9117202 | 0.86 | PTGS2 (0.47) | PTGS2PTGS1KIF11 | |
| SCHEMBL9117809 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1KIF11ELANE | |
| SCHEMBL9117982 | 0.84 | PTGS2 (0.69) | PTGS2PTGS1KIF11 | |
| SCHEMBL8974287 | 0.83 | KIF11 (0.56) | PTGS2PTGS1KIF11ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | claimed |
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |