Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | IDH2 | P48735 | 4/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117246 | 0.94 | RAF1 (0.52) | PTGESALOX5IDH2RAF1BRAF | |
| SCHEMBL8432579 | 0.94 | PTGES (0.58) | PTGESALOX5IDH2HTTMEN1 | |
| SCHEMBL8433479 | 0.91 | PTGES (0.49) | PTGESALOX5IDH2RAF1HTT | |
| SCHEMBL9116337 | 0.90 | P2RY1 (0.45) | MEN1MAPTKMT2ARAB9ALMNA | |
| SCHEMBL9118546 | 0.90 | RAF1 (0.52) | PTGESALOX5RAF1MEN1MAPT | |
| SCHEMBL9117651 | 0.89 | HTT (0.56) | HTTMEN1MAPTKMT2ALMNA | |
| SCHEMBL9117910 | 0.88 | PTGES (0.46) | PTGESALOX5IDH2HTTMEN1 | |
| SCHEMBL9243116 | 0.87 | IDH2 (0.46) | IDH2RAF1HTTMEN1MAPT | |
| SCHEMBL8432745 | 0.86 | PTGES (0.48) | PTGESALOX5BRAF | |
| SCHEMBL9289620 | 0.84 | PTGES (0.49) | PTGESALOX5IDH2RAF1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995033458-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | claimed |
| WO-1995033458-A1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |