Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121580 | 0.87 | CYP4F2 (0.47) | FOLH1SLC7A5PPARGPPARAHPGD | |
| SCHEMBL9122899 | 0.87 | FOLH1 (0.46) | FOLH1SLC7A5PPARGPPARAHPGD | |
| SCHEMBL9121439 | 0.85 | MEN1 (0.43) | PPARGPPARAMEN1KMT2AALDH1A1 | |
| SCHEMBL9119824 | 0.81 | MAPK1 (0.39) | PPARGPPARAALDH1A1 | |
| SCHEMBL8799650 | 0.79 | CYP4F2 (0.46) | FOLH1SLC7A5ALDH1A1HPGDRAB9A | |
| SCHEMBL18095490 | 0.76 | CYP4F2 (0.46) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL9118208 | 0.74 | PTGS2 (0.33) | PPARGPPARAMEN1KMT2AALDH1A1 | |
| SCHEMBL8799505 | 0.74 | ITGB3 (0.43) | PPARGPPARA | |
| SCHEMBL9118824 | 0.73 | PPARG (0.42) | FOLH1PPARGPPARAHPGD | |
| SCHEMBL9117679 | 0.72 | MAPK1 (0.47) | PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |