Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78327 | 0.80 | PDK1 (0.40) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL91296 | 0.78 | PDK1 (0.36) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL91304 | 0.77 | PDK1 (0.35) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL14420257 | 0.68 | POLB (0.48) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL25827425 | 0.66 | PDK1 (0.42) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL78407 | 0.65 | PDK1 (0.37) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL91259 | 0.65 | HTR2C (0.33) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL14420341 | 0.65 | HTR2C (0.41) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL91294 | 0.64 | PARP1 (0.39) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL78185 | 0.64 | PDK1 (0.40) | PDK1PDK2PDK3PDK4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |